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What is TB500 Peptide?

TB500 peptide, also known as Thymosin Beta-4, is a synthetic version of a naturally occurring protein in the human body. It plays a crucial role in wound healing, tissue regeneration, and the overall repair process [1].

When administered exogenously, Hong Kong research has found that TB500 can enhance recovery from injuries and aid in muscle repair by promoting cell migration and differentiation. This peptide has garnered attention for its potential to accelerate healing in various tissues, including ligaments, tendons, and skin. 

Molecular Formula: C212H350N56O78S

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Molecular Weight: 4963 g/mol

View the HPLC Certificate here. 

Source: PubChem

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Summary of TB500's Benefits:

Buy TB500 Peptide Vial here – Available in 2mg, 5mg & 10mg

TB500 Mechanism of Action

TB500 peptide exerts its effects through a variety of intricate mechanisms that contribute to its renowned healing and regenerative properties.

Firstly, TB500 promotes cell migration by activating pathways that facilitate the movement of cells to injured areas, aiding in tissue repair and regeneration. This migration is crucial for recruiting necessary cells to initiate the healing process effectively [2].

Furthermore, TB500 plays a pivotal role in reducing inflammation by modulating immune responses, inhibiting pro-inflammatory cytokines, and mitigating oxidative stress, thereby creating an environment conducive to healing without excessive inflammation.

Moreover, TB500 supports cardiovascular health and circulation by promoting angiogenesis, the formation of new blood vessels, which enhances blood flow to damaged tissues and organs [3].

Additionally, in muscle tissue, TB500 stimulates satellite cell migration to damaged areas, facilitating muscle repair and growth. The peptide also aids in the repair of various tissues, including ligaments, tendons, and skin, by accelerating wound healing processes and supporting tissue regeneration.

Overall, TB500’s multifaceted mechanisms of action make it a promising therapeutic agent for enhancing recovery, promoting tissue repair, and improving overall health outcomes.

Buy TB500 Nasal Spray from PharmaLabGlobal Hong Kong offering a convenient, non-invasive solution to your clinical research.

TB500 Mechanisms of action

Potential Applications of TB500 Peptide

TB500, a synthetic version of the naturally occurring peptide Thymosin Beta-4, has gained attention in Hong Kong scientific and medical communities for its potential applications based on research. 

Wound Healing and Tissue Repair: TB500 has garnered attention within medical communities for its profound impact on wound healing and tissue repair. Its mechanism, mirroring that of the naturally occurring Thymosin Beta 4, is pivotal in regenerating tissues and healing wounds [2]. TB500 facilitates this by promoting cell migration and proliferation, crucial for tissue regeneration. Additionally, its role in angiogenesis, the formation of new blood vessels, ensures an adequate blood supply to the damaged areas, expediting the healing process. 

Anti-Inflammatory: TB500’s anti-inflammatory properties offer a significant advantage in treating conditions characterised by inflammation. Its mechanism of action involves the modulation of cytokines, proteins that play a critical role in mediating inflammation. By reducing the levels of pro-inflammatory cytokines and increasing anti-inflammatory cytokines, TB500 directly combats inflammation at the molecular level. This attribute not only aids in reducing swelling and discomfort associated with inflammatory conditions but also promotes a more conducive environment for tissue repair and recovery. 

Stimulate Hair Growth: TB500’s potential in promoting hair growth is rooted in its cellular regeneration properties and enhanced blood circulation capabilities. By stimulating angiogenesis, TB500 increases blood flow to the scalp, ensuring a richer supply of nutrients and oxygen essential for hair follicle health. This process not only encourages the growth of new hair but may also strengthen existing hair, reducing hair loss [5].

Cardiovascular Protection: TB500’s potential to enhance cardiovascular health lies in its natural tissue repair mechanisms, including the promotion of new blood vessel formation and cell migration. These processes are crucial for repairing and maintaining the health of cardiac tissues. By fostering the development of new blood vessels, TB500 improves blood flow and oxygenation to the heart, which is essential for preventing heart-related medical conditions [3]. Additionally, its anti-inflammatory properties help in reducing chronic inflammation, a known risk factor for cardiovascular diseases [4].

Neuroprotective: TB500’s therapeutic potential extends to neuroprotection, where its tissue regeneration and anti-inflammatory properties may prove beneficial in safeguarding the nervous system. By stimulating angiogenesis and cell migration, TB500 could enhance the repair and growth of neural tissues, potentially improving outcomes in neurodegenerative diseases or following neurological injuries [6]. 

Buy TB500 Pre-Mixed Peptide Pen. PharmaLabGlobal Hong Kong supplies full pen kits with pre-mixed BPC-157 and Bacteriostatic Water refill cartridges.

Is TB500 legal?

Currently TB500 is only available for vitro testing in laboratory research purposes in the majority of countries, it is important to check the laws of the jurisdiction you currently reside. 

TB500 FAQs

Does TB500 increase muscle growth?

Whilst use of the product TB500 peptide can aid in tissue repair and recovery processes including bloody vessel growth, which may indirectly support muscle growth by promoting faster healing of muscle injuries, it is not typically used or recognized as a direct muscle-building compound like other peptides.

What are the side effects of TB500?

TB500 is available from PharmaLabGlobal for educational purposes in the use of laboratory experimentation. However researchers suggest that the side effects of TB500 are generally considered to be mild and rare, especially when used at appropriate dosages. Some reported side effects may include temporary redness or irritation at the injection site, fatigue, or drowsiness. However, it’s essential to note that individual responses to any substance can vary, and adverse reactions are always a possibility. 

What are the differences between BPC-157 and TB500?

While both peptides can aid in tissue repair and recovery processes, TB500 is more associated with musculoskeletal repair, while BPC-157 has a broader scope of healing properties and is particularly recognized for its effects on gut health.

Buy TB500 & BPC-157 Blend Hong Kong

Combining TB500 and BPC-157 peptides presents a synergistic approach to healing and tissue repair, capitalizing on the unique benefits of each research chemical. 

TB500 excels in promoting cell migration and angiogenesis, enhancing tissue regeneration and cardiovascular health. BPC-157, known for its potent healing properties, significantly improves wound healing, tendon repair, and gut health.

Together, these peptides provide a comprehensive healing strategy, accelerating recovery from injuries, reducing inflammation more effectively, and boosting the overall healing process. 

Further Hong Kong research has found that this combination has the potential to support not only athletes and individuals with injuries but also offers benefits in managing chronic conditions by promoting faster, more efficient tissue repair and reducing recovery times as demonstrated on animal models.

Buy TB500 BPC-157 Blend Peptide Vial here.

Scientific Research

[1] Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51.

[2] Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999 Sep;113(3):364-8.

[3] Spurney CF, Cha HJ, Sali A, Pandey GS, Pistilli E, Guerron AD, Gordish-Dressman H, Hoffman EP, Nagaraju K. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One. 2010 Jan 29;5(1):e8976

[4] Stark, C., Helenius, M., Taimen, P. et al. Thymosin beta 4 treatment improves left ventricular function after myocardial infarction and is related to Up-regulation of chitinase 3-like-1 in mice. transl med commun 1, 8 (2016)

[5] Gao XY, Hou F, Zhang ZP, Nuo MT, Liang H, Cang M, Wang ZG, Wang X, Xu T, Yan LY, Guo XD, Liu DJ. Role of thymosin beta 4 in hair growth. Mol Genet Genomics. 2016 Aug;291(4):1639-46.

[6] Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M. Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury. Ann N Y Acad Sci. 2012 Oct;1270:51-8.

Further Reading:

Injury Repair Peptides – The Science Behind Healing and Recovery

Injury peptides, such as TB500, are bioactive compounds that promote tissue healing, reduce inflammation, and support recovery from various injuries, ranging from muscle strains and ligament tears to surgical wounds and chronic conditions, by enhancing cellular repair mechanisms and tissue regeneration.

Find out more about Injury Repair Peptides here.

Unveiling the Potent Synergy of BPC-157 Thymosin Beta-4 Blend Capsules

Discover how BPC-157 & Beta-4 Capsules combine the regenerative properties of BPC-157 peptide with the healing effects of Beta-4 peptide in a convenient capsule form, aimed at supporting tissue repair, reducing inflammation, and promoting overall recovery from injuries and various health challenges.

Read more here.

The Ultimate Guide to Muscle Building Peptides from PharmaLabGlobal

Muscle building peptides are specialized compounds designed to enhance muscle growth, strength, and recovery by stimulating protein synthesis, increasing muscle mass, and improving exercise performance, offering athletes and fitness enthusiasts a targeted approach to achieving their muscle-building goals.         

Check out the full blog here.

Why Buy TB500 from PharmaLabGlobal?

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Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)

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At Pharma Lab Global we supply premium peptides to the research industry worldwide.

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At Pharma Lab Global we aim to supply the highest purity research peptides at affordable prices.